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The effect of gamma-hydroxybutyric acid(GHB)on ethanol withdrawal syndrome in alcoholics was investigated in a randomised double-blind study.Patients with withdrawal symptoms were treated either with GHB(orally in a syrup preparation)(11 patients)or with the syrup alone(12).GHB treatment(50 mg/ kg)led to a prompt reduction in withdrawal symptoms,such as tremors, sweating,nausea,depression,anxiety,and restlessness.The only side-effect was dizziness.GHB may be useful in the management of alcohol withdrawal syndrome in man. |
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